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Prophylactic efficacy of aerosol preparations based on Abies siberica polyprenols in experimental influenza infection

Sergeev, A.N.; Safatov, A.S.; P'iankov, O.V.; Bulychev, L.E.; Zhukov, V.A.; Alekseeva, A.G.; Petrishchenko, V.A.; Shishkina, L.N.; Poryvaev, V.D.; Glotov, A.G.

Voprosy Virusologii 46(6): 24-28

2001

ISSN/ISBN: 0507-4088
PMID: 11785383
Document Number: 527481
Preliminary investigations showed high preventive activity of two of three aerosol preparations of Abies sibirica polyprenols with nonionic surface active substances towards influenza infection. At least 2 aerosol administrations are needed to attain a high protective effect, the second dose depending on the first. Relationship between animal reaction to influenza virus infection changed in a nonmonotonous mode, depending on the drug dose injected during the first treatment: as the dose increased, the death rate first decreased and reached the minimum and then increased again. Such a reaction to aerosol treatment can be explained by the hypothesis of hyperstimulation followed by exhaustion of the host defense systems after high doses of the preparation.

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