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Highly reactive 4-membered ring nitrogen-containing heterocycles: Synthesis and properties

Alcaide, B.; Almendros, P.; Aragoncillo, C.

Current Opinion in Drug Discovery and Development 13(6): 685-697

2010

ISSN/ISBN: 1367-6733
PMID: 21061231
Document Number: 645640
4-Membered nitrogen-containing heterocycles, such as β-lactams (ie, 2-azetidinones) and azetidines, are useful substrates in organic chemistry for the design and preparation of biologically active compounds by functionalization of the different positions of the ring. In addition, these compounds are versatile building blocks for the synthesis of other types of nitrogen-containing compounds with potential biological properties. This review summarizes recent data regarding the preparation and properties of 4-membered nitrogen-containing heterocyclic rings, as well as their biological activities.

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Muylaert, K.; Jatczak, M.; Mangelinckx, S.; Stevens, C.V. 2014: Synthesis Of Pyrido-Annelated Seven-Membered N-Containing Heterocycles Current Medicinal Chemistry 2014
Mikhaĭlitsyn, F.S.; Kozyreva, N.P.; Rabinovich, S.A.; Maksakovskaia, E.V.; Kulikovskaia, I.M.; Dadasheva, N.R.; Lebedeva, M.N.; Bekhli, A.F.; Lychko, N.D.; Uvarova, N.A. 1992: The search for new antiparasitic agents. 10. the synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4-(4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine) Meditsinskaia Parazitologiia i Parazitarnye Bolezni 1: 50-53
Graczyk, J.; Kamińska, A.; Szadowska, A.; Tkaczyński, T.; Urbańska, A. 1976: Synthesis and pharmacological properties of some new diphenylacetic acid amides substituted at the nitrogen atom Acta Poloniae Pharmaceutica 33(5): 585-592
Kusenda, J.; Kalafut, F.; Klobusická, M.; Novotná, L. 1992: Tumoricidal properties of rat peritoneal macrophages activated with various activators depend on nitrogen oxid synthesis Neoplasma 39(1): 15-21
Metwally, M.A.; el-Hussiny, M.S.; el-Ablak, F.Z.; Khalil, A.M. 1989: Synthesis of some heterocycles of pharmaceutical interest Die Pharmazie 44(4): 261-265
Jung, N.; Encinas, A.; Bräse, S. 2006: Automated synthesis of heterocycles on solid supports Current Opinion in Drug Discovery and Development 9(6): 713-728
Zuo, Z.-z.; Zhong, H.; Cai, T.; Bao, Y.; Liu, Z.-q.; Liu, D.; Zhao, L.-x. 2015: Design, synthesis and antiproliferative activities of artemisinin derivatives substituted by N-heterocycles Yao Xue Xue Bao 50(7): 868-874
Metwally, M.A.; el-Hossini, M.S.; el-Ablak, F.Z.; Khalil, A.M. 1992: Synthesis of condensed heterocycles from 3-aryl-2,4-dicarbethoxy-5-methylcyclohexanones and their testing for antimicrobial activity Die Pharmazie 47(5): 336-339
Anjalika; Gupta, I.; Gupta, S.K.; Ganguly, N.K. 1999: Reactive oxygen intermediates and reactive nitrogen intermediates in copper intrauterine device users Contraception 59(1): 67-70
Grandolini, G.; Ambrogi, V.; Perioli, L.; Giannaccini, G.; Lucacchini, A.; Martini, C. 1996: Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. X--Synthesis and inhibition of benzodiazepine receptor binding of new 1,4-thiazine and 1,5-thiazepine polycondensed heterocycles with steroidal structure Farmaco 51(3): 203-207
Kawashima, E.; Sekine, T.; Miyahara, M.; Aoyama, Y.; Hirao, I.; Kainosho, M.; Kyogoku, Y.; Ishido, Y. 1992: Highly stereoselective synthesis of (2'R)-[2'-2H]-deoxyribonucleosides and synthesis of their oligonucleotides Nucleic Acids Symposium Series 27: 81-82
Puzanowska-Tarasiewicz, H.; Kuźmicka, L.ła.; Tarasiewicz, M.ła. 2009: Reactive nitrogen and oxygen species Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego 27(160): 338-340
Donetti, A.; Mantegani, A.; Marazzi-Uberti, E. 1970: Synthesis and aanalgesic activity of some compounds related to propoxyphene. II. Selective ring opening of an asymmetric epoxide with isobutenyllithium: an alternative synthesis of gamma-substituted allyl carbinols Il Farmaco; Edizione Scientifica 25(7): 500-508
Macásek, J.; Zeman, M.; Vecka, M.; Vávrová, L.; Kodydková, J.; Tvrzická, E.; Zák, A. 2011: Reactive oxygen and nitrogen species in the clinical medicine Casopis Lekaru Ceskych 150(8): 423-432
Ponczek, M.ł B.ła.; Wachowicz, B. 2005: Interaction of reactive oxygen and nitrogen species with proteins Postepy Biochemii 51(2): 140-145
Martin, J.H.; Edwards, S.W. 1993: Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactive oxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing Journal of Immunology 150(8 Pt 1): 3478-3486
Akopova, O.V.; Korkach, I.P.; Kotsiuruba, A.V.; Kolchyns'ka, L.I.; Sagach, V.F. 2012: Reactive nitrogen and oxygen species metabolism in rat heart mitochondria upon administration of NO donor in vivo Fiziolohichnyi Zhurnal 58(2): 3-15
Wanchu, A.; Agnihotri, N.; Deodhar, S.D.; Ganguly, N.K. 1996: Plasma reactive nitrogen intermediate levels in patients with clinically active rheumatoid arthritis Indian Journal of Medical Research 104: 263-268
Karimova, D.N.; Manukhov, I.V.; Gnuchikh, E.Y.; Farimov, I.F.; Deryabin, D.G. 2016: Reactive oxygen and nitrogen species' effect on lux-biosensors based on Escherichia coli and Salmonella typhimurium Prikladnaia Biokhimiia i Mikrobiologiia 52(3): 287-295
Sokolov, G.P.; Freĭmanis, I.F.; Turovskiĭ, I.V.; Myshliakova, N.V. 1995: Total synthesis and properties of prostaglandins. XXXVIII. Synthesis of 11-deoxyprostaglandin-E1 derivatives with amino acids and amines Bioorganicheskaia Khimiia 21(5): 386-390