Copper levels in certain tissues of rhesus monkeys and of women bearing copper IUDs.
The accumulation of copper in organs and tissues of rhesus monkeys and women bearing copper (Cu) IUDs (Copper T, Copper 200) was studied. In the animal study, there was no evidence of pathological changes in the endometrial, cervical, or vaginal mucosa, and there were no changes in tissue attributable to the copper. Serum levels of SGOT, SGPT, lactic acid dehydrogenase (LDH), copper, and blood urea nitrogen (BUD) were not markedly altered. However there were considerably higher concentrations of copper in the kidney and myometrium. In the human study, there was an initial rapid release of copper, in utero, for about 80 days, followed by a slowly declining rate of release. Mean serum concentrations of copper were not markedly altered, but there was a 2-fold increase in menstrual fluid copper content. There were marked increases in the copper content of endometrial tissues. There appeared to be a trend towards cyclic variations in endometrial copper content.