Progesterone as testosterone antagonist.

Kincl FA
In: Tanok, M., ed. Pharmacology of the endocrine system and related drugs: progesterone, progestational drugs and antifertility agents. Vol. 1. New York, Pergamon Press, 1971. (International Encyclopedia of Pharmacology and Therapeutics, Section 48) p. 325-329

A review of the literature on progesterone as a testosterone antagonist shows that progesterone will inhibit testosterone-elicited responses on the target organs in chicks, rats, and mice. While this field is still in its infancy, the evidence indicates that under specific conditions and in high amounts progesterone and related compounds may interfere with the action of testosterone or other androgens in various biological tests. The mechanism is unclear. It may be in circulating plasma or as a protective action at the target organ. To be of use in clinical medicine, antiandrogens, rather than affecting secretion in the gonads, would have to act at the target organ. The term "antiandrogenic" then is applied only to that form of action and would include not only progesterone but other synthetic progestational steroids.

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