Oral contraceptive for use by both males and females.

Sanyal SN
In: International Planned Parenthood Federation. The Sixth International Conference on Planned Parenthood. Theme: Family planning: Motivations an d methods, New Delhi, India, February 14-21, 1959. London, IPPF, (1959). p. 254-257

Chances of accidental unwanted pregnancy become negligibly small if both sexes use an effective and reliable contraceptive. The oral contraceptive (OC) m-xylohydroquinone was given to both men and women in trial studies to determine its contraceptive possibilities. When this OC was administered to large groups of women reductions in pregnancy up to 60% were noted. Even in the most adverse conditions a 50% reduction is assured. The trials showed that the drug was nontoxic and nonabortifacient in mothers as well as safe from ill effects in children born of drug failures. When m-xylohydroquinone was administered to rats and men sperm counts diminished following treatment and reverted to the original count after 4 days time. Complaints of side effects were absent in males during this study. The tenative conclusion is that the drug neutralizes the pituitary gonadotropin by complex formation thereby reducing the spermatogenic effect of the seminal epithelium of the testis. Other advantages to this drug include simple administration (2 doses per month), negligible cost, and possible effects on some forms of cancer. The OC has already been observed to counteract the effects of estrogen, progesterone, and gonadotropins.

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