Antifertility effects of Embelia ribes Burm.
Results of studies in female rats of the antifertility effect of Embelia ribes berries, its various extracts, and embelin, the putative active principle, are reported. When incorporated into the diet at both 10 and 20% dose levels, 62% antifertility activity was observed in treated animals. In the majority of these animals, the diestrous phase was prolonged within 2 weeks of treatment; however, no dose-duration effect was observed. At 15% doses, antifertility effect was observed in only 37% of animals. Serially hot-extracted petroleum ether and methanol extract affected cyclicity and prevented pregnancy in 75% of treated female rats. Benzene extract showed 51%, whereas chloroform extracts showed 37% antifertility activity. On the other hand, embelin (2,5-dihydroxy-3-undicyl-1, 4-benzoquinone), isolated from the E. ribes, failed to reveal any antifertility activity. These doses were all administered postcoitally, from Day 1-7 of pregnancy. Antifertility effect was assessed by number of implantation sites posttreatment.