Studies on the antifertility activity of embelin.
Antifertility studies on Embelin (Embelia Ribes (Vidanga)) showed that in 10-mg/kg oral doses given to albino rats from Day 1-Day 5 of pregnancy had 100% anti-implantation activity. The same dose of Embelin given to rabbits also exhibited highly significant (P < .001) antiovulatory activity, but no significant (P > .1) estrogenic or antiestrogenic effect in rats. Embelin was found to have a high margin of safety in acute toxicity studies in rats. Even at a high dose of 3 g/kg orally, it did not show any toxic effects. Subacute toxicity also indicated the drug was free from toxic side effects on bone marrow, liver, kidney, and heart.