[One thousand months of contraception with Sulpiride] Mille mois de contraception par le sulpiride.

Buvat J; Decroix-Blacker C; Legal F; Gasnault JP
Revue Francaise de Gynecologie et d'Obstetrique. 1976 Jan; 71(1):53-61.

Sulpiride, a psychotropic drug, was prescribed to 116 women for 1-36 months (mean 8.5) for contraception in patients for whom oral contraceptives were contraindicated (67), or not well tolerated (14), or primarily for psychiatric disorders and secondarily for contraception (38), or for psychiatric indications only (7). Doses ranged from 50 to 800 mg, usually 100 or 200 mg daily. Surveillance was divided into the observation phase with basal temperature curves and pregnenediol, vaginal smear, or endometrial biopsy as needed until an ovulation was confirmed, and the security phase after 60 days of a flat temperature curve, when amenorrhea usually persisted. Of 122 pregnenediol assays, 128 vaginal smears and 39 endometrial biopsies, 16 possible ovulations occurred in 11 women during observation and 2 during the security phase. There was 1 pregnancy in a woman who had been anovulatory for 6 months, but halved her dosage to 50 mg. To induce withdrawal bleeding every 2 or 3 months, chlormadinone acetate 2 mg and ethinyl estradiol 50 mcg was prescribed 2 times daily for 5 days. The side effects were stupor for the 1st few days, sleepiness in 20%, sedation in 43 cases, spontaneous galactorrhea in 25 cases, induced galactorrhea in all but 4 patients (considered a criterion of anovulation), weight gain of 3 kg in 23 cases, failure of further weight loss in 10 patients on reducing diets, vein disorders in 9, menstrual irregularity in 34, persistent amenorrhea after stopping in 5, and transient loss of libido in 2.

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