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Acquired immunodeficiency syndrome: meeting of the WHO Collaborating Centres on AIDS.

MMWR. Morbidity and Mortality Weekly Report. 1985 Nov 8; 34(44):678-9.

This report summarizes positions developed at a September 1985 meeting of Collaborating Centers on Acquired Immunodeficiency Syndrome (AIDS). Among these positions were the following: 1) the only practical methods currently available for routine, large-scale AIDS testing involve screening for antibodies to lymphadenopathy-associated virus/human T-lymphotropic virus type III (LAV/HTLV-III); 2) all sera reactive for LAV/HTLV-III antibodies should be confirmed by immunoprecipitation or immunoblot; 3) transfusion-associated AIDS can be eliminated by screening all units of blood and excluding donors from high-risk groups; 4) reuse of unsterile needles should be discouraged; 5) successful therapy may involve a combination of antiviral agents and substances that enhance immune responsiveness; 6) new antiviral drugs require careful study using the procedures of classical drug evaluation protocol, under the guidelines of national control authorities; 7) placebo-controlled studies in patients with mild forms of disease due to LAV/HTLV-III infection should be encouraged, since such studies will provide an answer on the efficacy of a drug more quickly and with fewer cases than the use of historic controls; 8) the prevalence of AIDS will depend heavily on the success of risk reduction programs based on public information and education; 9) the administration of live-virus vaccines could pose a theoretical risk to immunodeficient patients, although no adverse reactions have been detected to vaccines in individuals with antibody to LAV/HTLV-III; 10) T-lymphotropic retroviruses of simians provide potentially valuable models for studying the treatment of AIDS; and 11) an important aspect of World Health Organization activities on AIDS will be the collection of data on the incidence of the disease or its causative virus.

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