Cut-off hematocrit value for hemoconcentration in dengue hemorrhagic fever [letter]

Balasubramanian S; Anandnathan K; Shivbalan S; Datta M; Amalraj E
Journal of Tropical Pediatrics. 2004 Apr; 50(2):123-124.

Dengue is emerging as a global health problem and WHO has formulated guidelines for the diagnosis and management of dengue. As per WHO guidelines, hemoconcentration is one of the diagnostic criteria for dengue hemorrhagic fever (DHF). Hemoconcentration, defined as a 20 per cent rise in hematocrit, is difficult to ascertain with a single hematocrit value. Thus diagnosis of hemoconcentration is often retrospective. An area-specific hematocrit value would help in the early diagnosis and management in DHF.3 We undertook a study to determine the hematocrit value, which could be predictive of hemoconcentration in DHF in the Indian population. Eighty-eight hospitalized cases of DHF were studied. The diagnosis and management were based on WHO guidelines. Hematocrit values were obtained at the time of admission. Subsequent values were obtained once every 12–24 h or as and when the clinical situation warranted. Children posted for elective surgery during the same time period were taken as controls and their hematocrit was estimated. Statistical analysis was carried out using SPSS package version 10. The values were analysed using the receiver operator curve (ROC), i.e., sensitivity against 1-specificity. (excerpt)

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