Does relaxed reproductive selection explain the decline in male reproductive health? A new hypothesis [letter]

Czeizel AE; Rothman KJ
Epidemiology. 2002 Jan; 13(1):113-114.

One hypothesis that has been advanced to explain this decline in male reproductive health is that some environmental exposures act as "endocrine disruptors." These endocrine-disrupting chemicals are hypothesized to exert antiandrogenic effects on developing male fetuses and children. Although we have no evidence to offer against this hypothesis, we offer here an alternative hypothesis for a decline in male reproductive health. Our hypothesis is based on the proposition that until recent times there has been strong natural selection against poor reproductive health, but in the past few decades this selective pressure has been relaxed. (author's)

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