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Journal of Tropical Medicine and Hygiene. 1980 Dec; 83(6):259-64.The status of Plasmodium falciparum resistance to chloroquine in Sabah, Malaysia was not known until 1971-72. In 1974 resurgence of malaria was 77% over the number of cases in 1973 despite a malaria control program. Several in-vivo studies and 1 in-vitro study were conducted from 1971-5 and showed 51% out of 57 cases were resitant to chloroquine, the substance most widely used in the control program. 1 study was started in 1978 to continue to 1980; the preliminary results show 65 cases (85%) out of 76 successful tests are chloroquine-resistant. A decision was made to change to Fansidar for treatment of P. falciparum infection and to make other changes in the anti-malaria campaign in 1978-79 such as switching to emulsion concentrate for DDT insecticide spraying and monthly mass drug administration in serious transmission areas.