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In: AIDS and associated cancers in Africa, edited by G. Giraldo, E. Beth-Giraldo, N. Clumeck, Md-R. Gharbi, S.K. Kyalwazi, G. de The. Basel, Switzerland, Karger, 1988. 292-302.The global strategy of AIDS prevention, managed by the WHO Special Programme on AIDS (SPA) was created in 1987, and is intended to be as intense as the smallpox eradication campaign. Its objectives are to prevent HIV transmission, to care for HIV-infected persons and reduce morbidity and mortality, and to unify national AIDS programs. AIDS can be prevented because it in only transmitted by 3 routes, sexual, blood and perinatal. AIDS-infected persons must be provided with medical, psychological and social support, without discrimination. The key elements of a national AIDS program are political openness, creation of a national AIDS committee, initial epidemiologic and resource assessment, and development of a medium-term AIDS plan. The plan should include epidemiological surveillance, laboratory capability, education programs for health workers, prevention of sexual transmission, prevention of blood transmission, prevention of intravenous drug abuse, strict single-use of medical and traditional skin-piercing instruments, and prevention of infection of women of childbearing age altogether. HIV-infected women should receive acceptable contraceptive methods. Evaluation of national programs is vital not only to maximize limited resources, but to discover how HIV prevention can best be achieved.