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    765934

    New developments in the management of male fertility.

    KEOGH EJ

    In: International Planned Parenthood Federation (IPPF). East and South East Asia and Oceania region. Joint consultation of regional medical committee and regional information, education and communication committee, March 2-3, 1976, Hong Kong. Kuala Lumpur, Malaysia, IPPF, (1976). p. 76-79

    This IPPF review discusses chemical and hormonal male contraceptive agents and their effects on the physiology of testicular control. 2 methods of physiological disruption are addressed: direct interruption of spermatogenesis and suppression of gonadotropins (steroidogenesis). Sperm production may be interrupted by 1) agents acting directly on the seminiferous tubule to arrest cell division, 2) by interference with epididymal function, 3) or by blocking secretion of follicle stimulating hormone (FSH) and luteinizing hormone on which the testis and epididymis depend. Agents now being tested for these purposes show no promise except for cyproterone acetate, given in low doses of 10 and 29 millig/day, which has biomodal action. Gonadotropin suppression requires analogues of either gonadotropin-releasing hormone or androgens, though loss of libido and potency occur with administration. Of the drugs discussed, none fulfills criteria of a desirable male contraceptive. Androgens alone or with progestagens and estrogens have been shown to be effective, but side effects and mode of administration require further study. Inhibin, a postulated FSH inhibitor, theoretically provides a novel approach in that it is a peptide and libido should not decrease; however, oral male contraception seems a decade away.
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