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Cyproterone acetate (CPA) a potential male contraceptive: further studies on the interactions with endocrine parameters.
Berlin, Germany, WHO-CCCR, . 11 p.This unpublished paper is the transcript of a conference proceeding, but the figures referred to textually are not included in the document. This study evaluated the effects of medium dose cyproterone acetate (CPA), 10-30 mg/day, on gonadotropin and peripheral androgen levels. On the average, luteinizing hormone (LH) concentrations were about 35% lower during CPA administration; similar observations were made for follicle stimulating hormone (FSH). CPA medication resulted in a significant reduction of LH response to LH-releasing hormone (RH); FSH increments following LH-RH stimulation were considerably smaller than those of LH and were hardly distinguishable from spontaneous FSH fluctuations. LH-RH double stimulation resulted in a slow but continuous rise of T without distinct peaks of borderline significance. CPA administration caused a highly significant elevation of serum prolactin in 7/10 males. In summary, medium dose CPA exerted the following effects on the hypothalamo-pituitary-testicular axis during the 1st 12 weeks of administration: 1) suppression of basal LH, FSH, T, and dihydroT; 2) abolition of the spiking phenomenon of androgen secretion; 3) suppression of LH-RH mediated secretion of LH and FSH; and 4) elevation of basal prolactin.
In: Sciarra, J.J., Markland, C. and Speidel, J.J., eds. Control of male fertility. (Proceedings of a Workshop on the Control of Male Fertility, San Francisco, June 19-21, 1974). Hagerstown, Maryland, Harper and Row, 1975. p. 274-307Literature on research approaches to permanent and relatively reversible methods of male fertility control is reviewed. Sources and expenditures for research into male fertility control are noted. Permanent methods discussed include electrocautery of the vas, transcutaneous interruption of the vas, vasectomy clips, chemical occlusion of the vas, and passive immunization. Reversible methods reviewed include vasovasotomy, intravasal plugs, and vas valves. Current research into animal models, reversibility after vas occlusion, nonocclusive surgical techniques, pharmacological alteration of male reproductive function, including adrenergic blocking agents, steroidal compounds, inhibitors of gonadotropin secretion, clomiphene citrate, organosiloxanes, prostaglandins, alpha-chlorohydrin, heterocyclic agents, and alkylating agents, and delivery systems for antifertility agents is discussed. Research into semen storage and improved condoms is also reviewed. As a relatively low proportion of funds are committed to research in male fertility control, a greater investment in applied and clinical research is warranted.