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    179488

    Vaccines -- in Uganda, it's personal.

    Monico SM

    Global AIDSLink. 2003 Jun-Jul; 12.

    A bill was drafted and finally endorsed in early 1998 stating that the vaccine candidate had a favorable safety profile from pre-clinical and clinical testing in the country of origin; that there was evidence of clear benefit to the population; that there was a Memorandum of Understanding affirming interaction between UNAIDS/WHO manufacturers/sponsoring agencies and Ugandan representatives; and that the final decision about the vaccine candidate would be made by the government of Uganda, and endorsed by the parliament. The media closely followed these processes and, in February 1998, 40 army men -- a cohort that had undergone intensive preparation for 18 months since 1994 -- became the first volunteers recruited for the study. Despite the protracted nature of the process, it paved the way for other vaccine candidates to enter Uganda with minimal resistance, in an environment with the necessary infrastructure and level of community preparedness. Uganda now has an HIV Vaccine Preparedness Plan and, while the ALVAC trial ended successfully in 2001, three other vaccine candidates have already found their way into the country. (excerpt)
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