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    075203
    Peer Reviewed

    The role of GnRH analogues in male contraception.

    Waites GM

    CONTRACEPTION. 1992 Aug; 46(2):103-4.

    WHO formed its Task Force on Methods for the Regulation of Male Fertility in 1972. Its charge is developing safe, effective, reversible, and affordable contraceptive methods for developing countries. The research focus is on suppression of sperm production. The research strategy consists of 3 parts: suppression of secretion of the pituitary gonadotropin hormones, recouping circulating androgen to physiological levels without prompting spermatogenesis, and determining the functional ability of residual sperm if treatment does not bring about azoospermia in all cases. A task Force study reveals that men of various ethnic groups respond to testosterone contraceptives differently. Other clinical research involved an androgen with a progestogen such as DMPA. Since steroids are basically inexpensive to produce they may prove to be beneficial and affordable to national family planning programs in developing countries. Gonadotropin releasing hormone (GnRH) antagonists proved to be relatively effective in suppressing gonadotropins and sperm production in animals. Scientists working on developing GnRH antagonists should strive to formulate a reversible contraceptive with no side effects which requires limited injections. The Task Force carried out a study in bonnet monkeys with the GnRH agonist buserelin in which buserelin suppressed spermatogenesis for 3 years and, after treatment, testicular function was entirely restored. Subsequent mating trials indicated they were fertile. The Task Force planned to follow the study with a GnRH antagonist. The 1st international gathering on GnRH analogues in China served to bring together scientists the world over to meet and to collaborate in developing new drugs for contraceptive use.
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