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Bulletin of the World Health Organization. 2011 May 1; 89(5):390-2.This article focuses on antimicrobial resistance, which challenges the control of infectious diseases, jeopardizes progress on health outcomes by increasing morbidity and mortality, and imposes huge costs on societies. It discusses several aspects related to antimicrobial resistance including: the lack of commitment and data, un-assured drug quality, poor prevention and control of infections, and weaker research efforts. It concludes by outlining the World Health Organization's policy package to combat antimicrobial resistance, which reframes the critical actions to be taken by governments to stimulate change by all stakeholders.