| 1. Title: Dominant lethal mutations and antifertility effects of di-2-ethylhexyl adipate and diethyl adipate in male mice. Author: Singh AR; Lawrence WH; Autian J Source: Toxicology and Applied Pharmacology 32(3): 566-576. 1975. Abstract: Dominant lethal mutations and antifertility effects of di-2-ethylhexyl adipate (DEHA) and diethyl adipate (DEA) were investigated in male mice. A single dose of DEHA or DEA was administered; to male mice which were then mated with 2 virgin females/week for 8 weeks. The acute LD50 for DEA was 2.19 ml/kg with 95% confidence limits of 2.04-2.35 ml/kg. The acute LD50 for DEHA was greater than 100 ml/kg. Both DEHA and DEA produced dose-dependent antifertility and mutagenic effects as indicated by reduced percentage of pregnancies and increased numbers of early fetal deaths, respectively. The higher doses produced a distinct reduction in incidence of pregnancy, especially during the 1st 3 or 4 weeks. A reduction in the number of implantations and live fetuses/pregnancy was seen for both adipates. Mutational effects occurred mainly during the postmeiotic stage of spermatogenesis, however, some mutagenic effects occurred during the premeiotic stage in mice treated with DEHA. It is concluded that early fetal deaths and semisterility constitute some of the genetic and reproductive effects elicited from administration of adipates to male mice subsequently mated to untreated females. Statistical analyses are included. Language: English Keywords: ANIMALS, LABORATORY | CONGENITAL ABNORMALITIES | CHROMOSOME ABNORMALITIES | SPERMATOGENESIS | IMPLANTATION | Clinical Research | Research Methodology | Neonatal Diseases and Abnormalities | Diseases | Reproduction | Pregnancy, First Trimester | Pregnancy Document Number: 752409 |
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