1.  Title: Things to come: Nano-technology and HIV prevention. Author: Wolbring G Source: Contact. 2006 Aug;(182):36. Abstract: The Australian pharmaceutical company Starpharma performs research on an nano-technology-based anti-microbial gel which prevents HIV infection of cells. The vaginal gel, SPL7013, uses nanoparticle called dendrimers to encapsulate and disable HIV. "VivaGel had good results in Phase 1 human clinical trials: it appears to be non-toxic, non-irritating, and successful at preventing HIV and genital herpes" . Studies also show that viruses are not evolving resistance to the microbicide. The product is now in expanded phase 1-2 trials, being tested around the world in various populations. It still has along way to go but the indications are positive. The United States' National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) signed a $20.3 million contract to fund VivaGel development for HIV prevention in October 2005. Two months ago, the NIAID signed another agreement to fund clinical trials of VivaGel aimed to study its application for genital herpes prevention. The United States Food and Drug Administration has granted VivaGel fast track status, which will be beneficial for phase 3 trials, cutting in half the time it takes for product registration and getting the product to market. The Food and Drug Administration's support of VivaGel has been something of a landmark as this is the first dendrimer to go through its system. (excerpt) Language: English Keywords: AUSTRALIA | UNITED STATES | PROGRESS REPORT | EVALUATION | WOMEN | HIV PREVENTION | TECHNOLOGY | VAGINAL GEL | MICROBICIDES | RESEARCH AND DEVELOPMENT | PRIVATE SECTOR | USFDA | PRODUCT APPROVAL | Oceania | Developed Countries | North America | Americas | Demographic Factors | Population | HIV Infections | Viral Diseases | Diseases | Economic Factors | Vaginal Spermicides | Contraceptive Methods | Contraception | Family Planning | Drugs | Treatment | Medical Procedures | Medicine | Health Services | Delivery of Health Care | Health | Macroeconomic Factors | USPHS | Government Agencies | Organizations | Political Factors | Sociocultural Factors | Legislation Document Number: 314854 |
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