| 1. Peer Reviewed Title: Evaluation of lipid profile in adolescents during long-term use of combined oral hormonal contraceptives. [Evaluación del perfil lipídico en adolescentes durante el uso a largo plazo de anticonceptivos hormonales orales] Author: Guazzelli CA; Lindsey PC; de Araújo FF; Barbieri M; Petta CA Source: Contraception. 2005;71:118-121. Abstract: The study evaluated the effects of the long-term use of a combined oral hormonal contraceptive containing 30 µg ethinyl estradiol and 75 µg gestodene in adolescents. Thirty-three volunteers, aged from 14 to 19 years, who used the oral contraceptive for three consecutive years, were studied. Evaluation of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides was made before use and after 1, 2 and 3 years. During the 3-year study period, total cholesterol, HDL-C, LDL-C and triglyceride levels were significantly higher than previous measurements, but average values did not exceed the normal range. Compared to the first year, the second- and third-year cholesterol, HDL-C, LDL-C and triglyceride levels were not significantly different. (author's) Spanish Abstract: El estudio evaluó los efectos del uso a largo plazo de anticonceptivos hormonales orales combinados con contenido de 30 µg de etinil-estradiol y 75 µg de gestodeno. Se estudiaron treinta y tres voluntarias de 14 a 19 años que emplearon el anticonceptivo oral durante tres años consecutivos. Previo a la administración, al año, a los dos y a los tres años se evaluaron colesterol total, colesterol de lipoproteínas de alta densidad (HDL-C, high-density lipoprotein cholesterol), colesterol de lipoproteínas de baja densidad (LDL-C, low-density lipoprotein cholesterol) y triglicéridos. Durante el período del estudio de 3 años, los niveles de colesterol total, colesterol de lipoproteínas de alta densidad, colesterol de lipoproteínas de baja densidad y triglicéridos fueron significativamente superiores a las mediciones previas, pero los valores promedio no superaron el rango normal. Los niveles de colesterol total, HDL-C, LDL-C y triglicéridos para el segundo y tercer años no difirieron significativamente de los valores registrados en el primer año. (del autor) Language: English Keywords: BRAZIL | RESEARCH REPORT | EVALUATION | ADOLESCENTS, FEMALE | ORAL CONTRACEPTIVES, COMBINED | ETHINYL ESTRADIOL | GESTODENE | LONGTERM EFFECTS | CHOLESTEROL | LIPIDS | RISK FACTORS | HEALTH | Developing Countries | South America, Eastern | South America | Latin America | Americas | Adolescents | Youth | Age Factors | Population Characteristics | Demographic Factors | Population | Oral Contraceptives | Contraceptive Methods | Contraception | Family Planning | Contraceptive Agents, Estrogen | Contraceptive Agents, Female | Contraceptive Agents | Contraceptive Agents, Progestin | Time Factors | Population Dynamics | Physiology | Biology Document Number: 281343 |
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