POPLINE Document Number: 315033
Author(s):
Zimmermmann JB
Melo VH
de Castro LP
Alves MJ
Zimmermmann SG
Source citation:
Revista Brasileira de Ginecologia e Obstetricia, 2006 Jun;28(6):345-351.
Abstract:
The purpose was to evaluate association between CD4+ cell count and cervical intraepithelial lesion severity in HIV-infected women. Cross-sectional study of 87 HIV-infected patients which were confirmed by previous serologic examinations. All had cervical HPV diagnosed by polymerase chain reaction (PCR). All patients underwent anamnesis, physical examinations and colposcopy. Cervix biopsy was performed when indicated by colposcopical examination. Histopathological results followed Richart's classification, adapted by Wright, and CD4+ cell count and cervical intraepithelial lesion severity association was analysed by comparison of means using analysis using analysis of variance (ANOVA).Among 60 biopsied women 24 were found (40.0%) with CIN I, eight (13.3%) with CIN II, three (5%) with CIN III, 14 (23.3%) with chronic cervicitis and 11 with cytopathic effect of HPV, without cell polarity loss. This corresponds to 35 (58.3%) women with intraepithelial lesion of low grade (CIN I + HPV) and 11 (18.3%) with intraepithelial lesion of high grade (CIN II + CIN III). There was no significant association between CD4+ cell count mean and cervical intraepithelial lesion severity (p=0.901).There was no association between CD4+ cell count and cervical intraepithelial lesion severity diagnosed by histopathological examination. (author's)
Keywords:
Research ReportIndex page
Cross Sectional Analysis
HIV Positive Persons
Women
Cervical Effects
HPV
Laboratory Examinations and Diagnoses
Immunologic Factors
Research Methodology
Persons Living With HIV/AIDS
HIV Infections
Viral Diseases
Diseases
Demographic Factors
Population
Cervix
Uterus
Genitalia, Female
Genitalia
Urogenital System
Physiology
Biology
Examinations and Diagnoses
Medical Procedures
Medicine
Health Services
Delivery of Health Care
Health
Immunity
Immune System