POPLINE Document Number: 313271
Author(s):
Pehlivanov B
Mitkov M
Source citation:
European Journal of Contraception and Reproductive Health Care, 2007 Mar;12(1):30-35.
Abstract:
Objective: To investigate the efficacy of a combined oral contraceptive containing 30 ethinyloestradiol and 3 mg drospirenone in the treatment of hyperandrogenism affecting women with the polycystic ovary syndrome (PCOS). Methods: Prospective open study of 20 women for six cycles. At the beginning and at the end of the study the following values were determined: the Ferriman-Gallwey (F-G) score, body mass index, waist/hip ratio, serum levels of testosterone, SHBG, immune reactive insulin (IRI), glucose, the free androgenic index, and insulin resistance (HOMA-IR). Results: All 20 women completed six cycles of therapy. The medication was well tolerated. At the end of the study there was a significant improvement of hirsutism, expressed in the decrease of the F-G score, accompanied by a decrease of testosterone and an increase SHBG values. The carbohydrate metabolism was not affected significantly. Conclusion: The combined oral contraceptive containing 30 mg ethinyloestradiol and 3 mg drospirenoneis an effective drug in the treatment of hyperandrogenism in women with PCOS; it elicits few side effects and does not significantly influence insulin resistance. (author's)
Keywords:
BulgariaIndex page
Research Report
Clinical Research
Prospective Studies
Women in Development
Oral Contraceptives
Contraceptive Effectiveness
Ovarian Cysts
Anthropometry
Testosterone
Hematological Effects
Glucose Metabolism Effects
Immunological Effects
Androgens
Carbohydrate Metabolic Effects
Europe, Southeastern
Europe
Developing Countries
Research Methodology
Studies
Economic Development
Economic Factors
Contraceptive Methods
Contraception
Family Planning
Diseases
Measurement
Hormones
Endocrine System
Physiology
Biology
Hemic System
Metabolic Effects
Immunity
Immune System