Title: Induction of labor in great grandmultipara with misoprostol.

POPLINE Document Number: 299904

Author(s):

Zeteroglu S
Sahin HG
Sahin HA

Source citation:

European Journal of Obstetrics, Gynecology and Reproductive Biology, 2006 May 1;126(1):27-32.

Abstract:

The objective was to compare the efficacy and complications of intravaginal misoprostol application with oxytocin infusion for induction of labor in great grandmultiparous pregnancies with a Bishop score of < 6. Sixty-four great grandmultiparous (delivering the tenth, or greater, infant) pregnant patients with a Bishop score of <6 were randomized in two groups with 32 patients receiving 50 mg intravaginal misoprostol four times with 4 h intervals, and 32 patients receiving oxytocin infusion for induction of labor starting from 2 mIU/min, increasing it every 30 min with 2 mIU/min increments up to maximum of 40 mIU/min. The time from induction to delivery, the route of delivery, fetal outcome and maternal complications were recorded. Statistical analyses were performed using Mann-Whitney U-test, Chi-Square test and hypothesis test about differences for two proportions (t-test) to determine differences between the two groups. P = 0.05 was considered significant. The mean time from induction to delivery was 9.91 ± 4.30 and 10.88 ± 4.72 h in the misoprostol and oxytocin administered group, respectively, with no significant difference between the groups. The rate of vaginal delivery was 84.4 and 87.5% in the misoprostol and oxytocin administered group, respectively, with no significant difference between the groups (P = 0.72). The rates of placental abruption and postpartum hemorrhage were similar in both groups and no case of uterine rupture occurred. The 1 and 5 min mean Apgar scores were 6.91 ± 1.57-8.88 ± 1.39 and 7.22 ± 1.24-9.06 ± 0.84 in the misoprostol and oxytocin administered group with no significant differences between the groups (P = 0.38 and 0.51). No case of asphyxia was present. The rate of admission to neonatal intensive care unit was higher in the misoprostol administered group, but the difference was not significant. Intravaginal misoprostol is an alternative method to oxytocin in induction of labor in great grandmultiparous pregnant women with low Bishop scores, as it is effective, cheap and easy to use. Safety about rare complications and neonatal morbidity needs clarifications with further studies. (author's)

Keywords:

Turkey
Research Report
Clinical Research
Pregnant Women
Women in Development
Multiparity
Misoprostol
Childbirth
Time Factors
Prostaglandins, Administration and Dosage
Oxytocin
Pregnancy Complications
Cost Effectiveness
Safety
Europe, Southeastern
Europe
Developing Countries
Research Methodology
Population Characteristics
Demographic Factors
Population
Economic Development
Economic Factors
Parity
Fertility Measurements
Fertility
Population Dynamics
Prostaglandins, Synthetic
Prostaglandins
Endocrine System
Physiology
Biology
Pregnancy Outcomes
Pregnancy
Reproduction
Pituitary Hormones
Hormones
Diseases
Evaluation Indexes
Quantitative Evaluation
Evaluation
Public Health
Health