Title: Vitamin D status in adolescents and young adults with HIV infection.

POPLINE Document Number: 299871

Author(s):

Stephensen CB
Marquis GS
Kruzich LA
Douglas SD
Aldrovandi GM

Source citation:

American Journal of Clinical Nutrition, 2006 May;83(5):1135-1141.

Abstract:

Vitamin D status affects immune function and thus may affect the progress of HIV infection. Our goals were to assess vitamin D intake and status in subjects with HIV infection and in matched control subjects and to determine whether HIV infection was associated with vitamin D insufficiency. Plasma 25-hydroxyvitamin D [25(OH)D] concentrations and vitamin D intake were measured in a cross-sectional study of members of the Reaching for Excellence in Adolescent Health (REACH) cohort. The subjects were aged 14-23 y; 74% were female, and 72% were black. Mean (±SE) vitamin D intake from food was 30% greater (P = 0.023) in HIV-positive subjects (295 ± 18 I/d; n = 237) than in HIV-negative subjects (227 ± 26 I/d; n = 121). The prevalence of vitamin D supplement use was 29% (104 of 358 subjects) and did not differ significantly by HIV status (P = 0.87). Mean plasma 25(OH)D did not differ significantly (P = 0.62) between the HIV-positive (20.3 ± 1.1 nmol/L; n = 238) and HIV negative (19.3 ± 1.7 nmol/L; n = 121) subjects, nor was HIV status a significant predictor of plasma 25(OH)D when multiple regression analysis was used to adjust for other variables. The prevalence of vitamin D insufficiency [plasma 25(OH)D = 37.5 nmol/L] in the subjects was 87% (312 of 359 subjects). HIV infection did not influence vitamin D status. The prevalence of vitamin D insufficiency in both HIV-positive and HIV-negative REACH subjects was high, perhaps because these disadvantaged, largely urban youth have limited sun exposure. (author's)

Keywords:

United States
Research Report
Clinical Research
Case Control Studies
Cross Sectional Analysis
Adolescents
Youth
HIV Positive Persons
Vitamins and Minerals
Immunologic Factors
Food Supplementation
Deficiency Diseases
Prevalence
North America
Americas
Developed Countries
Research Methodology
Studies
Age Factors
Population Characteristics
Demographic Factors
Population
Persons Living With HIV/AIDS
HIV Infections
Viral Diseases
Diseases
Physiology
Biology
Immunity
Immune System
Nutrition Programs
Primary Health Care
Health Services
Delivery of Health Care
Health
Nutrition Disorders
Measurement