POPLINE Document Number: 299207
Author(s):
Madebo T
Lindtjorn B
Aukrust P
Berge RK
Source citation:
American Journal of Clinical Nutrition, 2003 Jul;78(1):117-122.
Abstract:
Knowledge of the antioxidant profile and its relation to lipid peroxidation in tuberculosis patients with or without accompanying HIV infection is scarce, particularly in developing countries. The objective was to further investigate the interaction between HIV, tuberculosis, and antioxidants and their relations with markers of oxidative stress in a large population of Ethiopians. In a cross-sectional study, we evaluated antioxidants and markers of oxidative stress in Ethiopian tuberculosis patients with (n = 25) and without (n = 100) HIV infection and in Ethiopian (n = 45) and Norwegian (n = 25) healthy control subjects. Concentrations of the antioxidant vitamins C and E and of vitamin A were significantly lower in tuberculosis patients than in healthy Ethiopians. Tuberculosis patients also had significantly lower thiol concentrations, particularly of the reduced forms. Tuberculosis patients, particularly those who were co-infected with HIV, had higher malondialdehyde concentrations than did control subjects. High malondialdehyde concentrations were associated with clinical severity as measured by the Karnofsky Performance Status Index and anthropometric scores. Ethiopian control subjects had lower concentrations of vitamin E and higher concentrations of malondialdehyde than did Norwegian control subjects. Our findings further support a link between oxidative stress, tuberculosis, and HIV infection. However, whether antioxidant supplementation will improve tuberculosis outcome or is of importance for its prevention should be further examined in future prospective studies. (author's)
Keywords:
EthiopiaIndex page
Norway
Research Report
Cross Sectional Analysis
Clients
Tuberculosis
HIV Infections
Vitamins and Minerals
Lipids
Metabolic Effects
Nutrition Indexes
Africa, Eastern
Africa South of the Sahara
Africa
Developing Countries
Europe, Northern
Europe
Developed Countries
Research Methodology
Program Activities
Programs
Organization and Administration
Infections
Diseases
Viral Diseases
Physiology
Biology
Nutrition
Health