POPLINE Document Number: 277022
Author(s):
Khairat MA
Source citation:
Egyptian Society of Obstetrics and Gynecology, 1999 Jan-Mar;25(1-3):85-92.
Abstract:
Objective: To determine between intrauterine (IUI) or Intraperitoneal insemination (IPI) combined with superovulation, as a better therapy for treating unexplained infertility before approaching more sophisticated assisted reproduction techniques. Design: A prospective randomised study of ninety-three couples with unexplained infertility. Setting: El-Galaa Maternity Teaching Hospital and a private clinic. Subjects: Ninety-three partners with unexplained infertility were divided at random into two groups. Group (A; n=60) and group (b; n=33) were treated by IPI and (IUI) respectively following controlled ovarian hyperstimulation. A total of 200 treatment cycles in both groups were studied. Outcome measures: Pregnancy rates (PR) per cycle and per couple, pregnancy outcome and complications of treatment. Results: 26 pregnancies occurred with 128 cycles of IPI and 7 pregnancies with 72 cycles of IUI, giving an overall PR of 35.4%. Pregnancy rates with IPI were 20.3% per cycle and 43.3% per couple compared to 9.7% per cycle and 21.2% per couple with IUI giving a significant statistical difference (P=0.0214). There were no significant statistical differences between the IPI and IUI groups with regard to abortion (26.9% and 28.6%), ectopic pregnancy (3.8% and 0%) and multiple pregnancy rates (15.4% and 14.3%; all twins) respectively. One patient only in the IPI group developed mild ovarian hyperstimulation syndrome and none in both groups had pelvic infection. Conclusion: This study shows that in the treatment of couples with unexplained infertility, IPI is more successful than IUI. It is safe, relatively inexpensive and can be performed as an office-procedure. We advise that it should be attempted before resorting to the costly, invasive and complicated assisted reproductive techniques such as GIFT, IVF and ICSI. (author's)
Keywords:
EgyptIndex page
Research Report
Clinical Research
Comparative Studies
Prospective Studies
Women in Development
Artificial Insemination
Pregnancy Rate
Africa, Northern
Africa
Developing Countries
Research Methodology
Studies
Economic Development
Economic Factors
Reproductive Technologies
Reproduction
Fertility Measurements
Fertility
Population Dynamics
Demographic Factors
Population