Title: Efficacy and safety of glyceryl trinitrate versus ritodrine for preterm labor.

POPLINE Document Number: 277013

Author(s):

Salem A

Source citation:

Egyptian Society of Obstetrics and Gynecology, 2001 Apr-Jun;27(4-6):347-354.

Abstract:

Objective: To compare the efficacy of tocolysis with glyceryl trinitrate (GTN) patch and intravenous ritodrine hydrochloride with respect to maternal side effects and neonatal outcome. Subjects and Methods: 57 singleton pregnancy with preterm labor and intact membrane between 28 and 34 weeks gestation were assigned randomly to receive either GTN patch (n = 27) or ritodrine hydrochloride infusion (n = 30). The principal outcomes assessed were prolongation of pregnancy for 48 hours, 7 days and until 34 weeks of pregnancy & maternal side effects and neonatal outcome. Results: Both GTN and ritodrine treated women were comparable in entery variable including age, parity, gestational age, contraction frequency and cervical dilatation & effacement. Delivery of women was delayed for 48 h, 7 days and until 34 weeks gestation in 77.8%, 59.2% and 44.4% of women respectively treated with GTN compared with 73.3%, 56.7% and 43.3% respectively among women received ritodrine (no significant difference). Average number of the side effects per patient was significantly (P <0.01) lower with GTN treatment than ritodine therapy. The neonatal outcome was similar in the two treatment regimens. Conclusion: GTN was as effective as ritodrine in suppressing preterm labor. Its use was associated with less frequent side effects. (author's)

Keywords:

Egypt
Research Report
Clinical Research
Comparative Studies
Women in Development
Pregnant Women
Infant
Premature Labor
Side Effects
Drugs
Pregnancy Outcomes
Africa, Northern
Africa
Developing Countries
Research Methodology
Studies
Economic Development
Economic Factors
Population Characteristics
Demographic Factors
Population
Youth
Age Factors
Pregnancy
Reproduction
Treatment