Title: Mammographic breast density associated with postmenopausal hormone replacement therapy.

POPLINE Document Number: 277012

Author(s):

Salem A
Ismail H
El-Nashar AB
Hegazy B
Gamal M

Source citation:

Egyptian Society of Obstetrics and Gynecology, 2001 Apr-Jun;27(4-6):337-346.

Abstract:

Objective: To study the mammographic density changes associated with three different regime of hormonal replacement therapy (HRT): either estrogen alone or estrogen in cyclic or continuous combination with progestogens in a patch rout. Subject and methods: Base line mammographic density was recorded for 100 postmenopausal women and after 1 year of administration of HRT. HRT therapy was in form of estrogen compound only (n = 25), estrogen in cyclic (n = 30) or continuous (n = 45) combination with progesterone. Mammographic density was quantified according to the Wolfe classification (1976). Results: An increase in mammographic density was more common among women receiving continuous combined HRT (57.8%) compared to cyclic (33.3%) and estradiol only (8%) treatment with significant difference between the three groups. Breast discomfort was more frequent (20%) among women using continuous combined regimen compared to (13.3%) and (8%) in cyclic combined and in estrogen only regimen respectively. Conclusion: Regime of HRT had different effect on mammographic density. The most density increase was associated with estrogen in continuous combination with progesterone. The least impact on mammographic density was with estrogen alone treatment. (author's)

Keywords:

Egypt
Research Report
Clinical Research
Comparative Studies
Women in Development
Mammogram
Hormone Replacement Therapy
Menopause
Estrogens
Progesterone
Pain
Africa, Northern
Africa
Developing Countries
Research Methodology
Studies
Economic Development
Economic Factors
Examinations and Diagnoses
Treatment
Reproduction
Hormones
Endocrine System
Physiology
Biology
Progestational Hormones
Signs and Symptoms
Diseases