Title: Comparing vaginal and buccal misoprostol when used after methotrexate for early abortion.

POPLINE Document Number: 276724

Author(s):

Wiebe ER
Trouton K

Source citation:

Contraception, 2004;70:463-466.

Abstract:

The primary objective of this study was to determine if buccal misoprostol was as effective as vaginal misoprostol in medical abortions. The secondary objectives were to compare side effects and acceptability. This was a randomized controlled trial of 600 µg misoprostol by the buccal or vaginal routes used 3 to 6 days after 50 mg/m2 methotrexate. The participants were women presenting for abortion at 49 days or less gestation. The outcome measures were the number of women who had aborted by Day 8, side effects and acceptability. Day 8 completion rate was 53.5% for the buccal route and 67.5% for the vaginal route (p=0.012). Side effects were similar in the two groups except that there was more burning with the buccal route. Overall acceptability and route acceptability were similar in the two groups. When used after methotrexate for early abortion, the vaginal route for misoprostol is more effective and preferred to the buccal route. (author's)

Keywords:

Canada
Research Report
Clinical Trials
Pregnant Women
Misoprostol
Emergency Contraception
Methotrexate
Contraceptive Agents, Side Effects
Contraceptive Safety
North America, Northern
Americas
Developed Countries
Clinical Research
Research Methodology
Population Characteristics
Demographic Factors
Population
Prostaglandins, Synthetic
Prostaglandins
Endocrine System
Physiology
Biology
Contraception
Family Planning
Drugs
Treatment
Contraceptive Agents
Safety
Public Health
Health