Title: Progestogen-only contraception in women at high risk of venous thromboembolism.

POPLINE Document Number: 276722

Author(s):

Conard J
Plu-Bureau G
Bahi N
Horellou M
Pelissier C

Source citation:

Contraception, 2004;70:437-441.

Abstract:

The objective of the study was to evaluate the venous impact of a progestogen-only contraception on women at high risk of venous thromboembolism (VTE). In this retrospective cohort study, 204 consecutive women at high risk of VTE were recruited between January 1992 and June 1997 and were prospectively followed. Women using chlormadinone acetate (CMA) at antigonadotropic doses (n=102) were matched by age and date of referral and history of venous thrombosis with women who had no hormonal contraception (n=102). During follow-up (mean of 33 months), nine episodes of VTE were observed: three in women receiving CMA and six in nontreated women. Using the Cox model to adjust for confounding variables such as age, thrombophilia and body mass index, the relative risk of VTE associated with the use of CMA was not significant [relative risk: 0.8 (0.2–3.9)]. These reassuring results need to be confirmed in other prospective studies. (author's)

Keywords:

France
Research Report
Clinical Research
Cohort Analysis
Prospective Studies
Case Control Studies
Women
Contraceptive Agents, Progestin
Thromboembolism
Contraceptive Safety
Gonadotropins
Europe, Western
Europe
Developed Countries
Research Methodology
Studies
Demographic Factors
Population
Contraceptive Agents, Female
Contraceptive Agents
Contraception
Family Planning
Embolism
Vascular Diseases
Diseases
Safety
Public Health
Health
Hormones
Endocrine System
Physiology
Biology