Title: Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection.

POPLINE Document Number: 194675

Author(s):

Joseph S
Jones FM
Laidlaw ME
Mohamed G
Mawa PA

Source citation:

Journal of Infectious Diseases, 2004 Aug 1;190(3):613-618.

Abstract:

We show that Ugandan adults coinfected with Schistosoma mansoni and human immunodeficiency virus type 1 (HIV-1) are able to mount S. mansoni–specific immune responses but that few such responses increase after treatment with praziquantel (PZQ). Levels of soluble wormantigen (SWA)–specific immunoglobulin (Ig) G1, IgG2, IgG3, IgG4, interleukin (IL)– 4, and IL-5 increased significantly in HIV-negative participants after treatment with PZQ, whereas most soluble egg antigen– specific antibody responses and levels of interferon-g were unaltered. Only levels of SWA-specific IL-5 increased in HIV- 1–coinfected participants after treatment. These deficiencies in immune responses may account for the previously reported increased susceptibility to infection and reinfection with S. mansoni in individuals coinfected with HIV-1. (author's)

Keywords:

Uganda
Research Report
Adults
Schistosomiasis
HIV Infections
Treatment
Laboratory Examinations and Diagnoses
Immunologic Factors
Developing Countries
Africa, Eastern
Africa, Sub Saharan
Africa
Age Factors
Population Characteristics
Demographic Factors
Population
Parasitic Diseases
Diseases
Viral Diseases
Examinations and Diagnoses
Immunity
Immune System
Physiology
Biology