POPLINE Document Number: 194566
Author(s):
Sidney S
Petitti DB
Soff GA
Cundiff DL
Tolan KK
Source citation:
Contraception, 2004 Jul;70(1):3-10.
Abstract:
Objective: To assess the relationship between venous thromboembolic disease (VTE) and use of low-estrogen dose (<50 µg) combined estrogen-progestin oral contraceptives (OC) and three thrombosis-related gene mutations in a United States population. Design: This case-control study was conducted in 1998–2000 among women ages 15–44 years who were members of the Kaiser Permanente Medical Care Program [KPMCP] (Northern and Southern California). Cases were women with incident VTE; about three times as many women frequency matched for age were randomly selected as controls from the KPMCP membership in the same years. Data were collected in a 1 h face-to-face interview; blood was drawn to extract DNA to test for gene polymorphisms. The analysis data set comprised 196 cases (mean age 35.3 years) and 746 controls (mean age 36.2 years). Results: The adjusted odds ratio (OR) for VTE associated with current OC use was 4.07 (95% confidence interval [CI]: 2.77– 6.00). The OR associated with OC use was higher for women who were obese than in the nonobese (p = 0.01 for likelihood test for interaction) and in women without predisposing medical conditions (p = 0.02 for interaction). The adjusted OR for VTE was 7.10 (95% CI: 2.33–21.61) in women with factor V Leiden (G1691A) mutation, 2.83 (95% CI: 0.70 –11.63) in women with prothrombin G20210A mutation and 0.26 (95% CI: 0.10–0.65) in women with the MTHFR C677T mutation. The OR for VTE in OC users with factor V Leiden mutation (11.32) was elevated more than in OC users without the mutation (3.20) and women with the mutation who were non-OC users (8.42), but confidence intervals overlapped. Conclusions: The risk of VTE is increased in users of low-estrogen OC formulations. Obese women appear to be at greater risk of VTE when using OCs. (author's)
Keywords:
United StatesIndex page
Research Report
Case Control Studies
Interviews
Women
Oral Contraceptives, Combined
Oral Contraceptives, Low-Dose
Thromboembolism
Genetics
Risk Factors
Obesity
Developed Countries
North America
Americas
Studies
Research Methodology
Data Collection
Demographic Factors
Population
Oral Contraceptives
Contraceptive Methods
Contraception
Family Planning
Embolism
Vascular Diseases
Diseases
Biology
Body Weight
Physiology