Title: [Plasminogen activator inhibitor 1 -- a new marker of increased thrombosis risk]

POPLINE Document Number: 079047

Author(s):

Hoang NH
Kuntz BM
Bruster HT

Source citation:

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1992 Jun 26;117(26):1019-22.

Abstract:

The plasma activity of plasminogen activator inhibitor 1 (PAI-1) was measured in 278 clinically healthy subjects (98 men, 180 women; mean age 26 [18-50] years). In 198 of them there were factors increasing the risk of thrombosis, such as smoking, overweight, and/or oral contraceptives (OCs). PAI-1 activity was within normal range (<4 U/ml) in male nonsmokers of normal weight and in female nonsmokers not taking OCs. In male smokers (5.76 +or- 1.93 U/ml) and in overweight subjects of both sexes (7.49 +or- 1.87 U/ml) PAI-1 was increased up to 10.6 U/ml as an indication of decreased fibrinolysis capacity. Nonsmoking females on OCs had lower PAI-1 levels (2.72 +or- 0.86 U/ml) than nonsmokers without hormonal intake (3.21 +or- 1.03 U/ml; P < 0.001). Apparently, the increased risk of thrombosis that occurs on OCs is not due to increased PAI-1 activity. (author's) (summaries in GER, ENG)

Keywords:

Germany
Laboratory Examinations and Diagnoses
Thrombosis
Risk Factors
Tobacco Use and Abuse
Sex Factors
Oral Contraceptives
Obesity
Europe, Central
Europe
Developed Countries
Examinations and Diagnoses
Thromboembolism
Embolism
Vascular Diseases
Diseases
Biology
Behavior
Population Characteristics
Demographic Factors
Population
Contraceptive Methods
Contraception
Family Planning
Body Weight
Physiology