Title: [Human immunodeficiency virus infection in hemophiliacs: prevalence and current clinical situation]

POPLINE Document Number: 076333

Author(s):

Lorenzo JI
Molina R
Arilla MJ
Dasi MA
Monteagudo E
Aznar JA

Source citation:

SANGRE, 1991 Dec;36(6):451-5.

Abstract:

In a retrospective study in Spain, a hemophiliac population observed since October 1985 were investigated. They consisted of 156 males (147 with hemophilia A and 9 with B) aged 1-69 years: 75 had grave hemophilia (the level of factor below 1 U/dl), 48 had moderate hemophilia (the factor level between 1 and 5 U/dl), and 33 had mild hemophilia (factor level over 5 U/dl). Starting in 1985 HIV serology tests were carried out to detect HIV antibodies by the enzyme-linked immunosorbent assay (ELISA), and positive cases were confirmed by the Western Blot test. 94 patients (60%) were found HIV seropositive, and they were all treated exclusively with factor concentrates subjected to viral attenuation-inactivation methods. 2 patients had never received hemoderivatives, 6 had been treated exclusively with cryoprecipitates or frozen plasma, and 148 received lyophilized concentrates of factor VIII or IX. 55 new cases were detected in 1983, 15 in 1984, 13 in 1985, 8 in 1986, and 3 later. The approximate time of seroconversion could be ascertained only in 19 cases which ranged from 3 to 28 months between September 1983 and May 1985. According to this estimation, 4 patients seroconverted in 1983, 7 in 1984, and 8 in 1985. 148 patients treated exclusively with factor concentrates with HIV prevalence of 64% were studied for different HIV incidence. 81% of those with grave disease had seropositivity compared with only 24% of those with the mild form (p <1.0001). 75% of those who received more than 100,000 IU were seropositive compared with only 24% of those whose dose did not exceed 10,000 IU (p < .002). Although the seropositivity was somewhat lower in patients over age 30 than in younger patients, this was not significant. Out of 94 HIV-positive patients, 73 were alive at the close of the study: 57 in CDC stage II-III and 16 in stage IV (3 with AIDS). 19 patients had died, 12 of them of AIDS: 5 in 1987, 2 in 1988 2 in 1989, 2 1990, and the last one in 1991.

Keywords:

Spain
Retrospective Studies
Cohort Analysis
Diseases
Hematological Effects
HIV Infections
AIDS
Testing
Treatment
Prevalence
HIV Testing
Causes of Death
Developed Countries
Europe, Southwestern
Europe
Studies
Research Methodology
Hemic System
Physiology
Biology
Viral Diseases
Measurement
Laboratory Examinations and Diagnoses
Examinations and Diagnoses
Mortality
Population Dynamics
Demographic Factors
Population