Title: [The ketamine-propofol combination in induced abortion]

POPLINE Document Number: 076254

Author(s):

Gianuario L
Luongo C
Vicario C
Chiefari M
Lettieri B
Bimonte D

Source citation:

MINERVA ANESTESIOLOGICA, 1991 Sep;57(9):554-5.

Abstract:

100 patients aged 18-45 years weighing 45-90 kg with anesthesiological risk of ASA 1 or 2 underwent voluntary interruption of pregnancy in a day hospital. In 50 propofol and fentanyl (P-F) and in the other 50 propofol and ketamine (P-K) were administered. In the P-F group iv preanesthesia consisted of 2 mcg/kg fentanyl + .5 mg of atropine. Induction of 2.5 mg/kg of propofol + 02 was by mask maintained by a .5 mg/kg propofol bolus according to need. In the P-K group preanesthesia was carried out by .5 mg of atropine iv. Induction took place by .5 mg/kg of ketamine, followed immediately by 1.75 mg/kg of propofol + 02 by mask when necessary and maintained by a .5 mg/kg propofol bolus as needed. Every 3 minutes the PAs (systolic arterial pressure), the PAd (diastolic arterial pressure), and the FC were monitored along with more frequent undesired effects and the time of postoperative recovery up to unassisted walking. The pre- and postinduction variation of PAs and PAd decreased 15-20% in the P-F group and 7-9% in the P-K group which returned to normal within 20 minutes after the intervention. The FC of the P-K group after propofol declined about 8% compared with about 14% in the P-F group returning to normal value 15-20 minutes after the interventions. Postinductive apnea was found more frequently in the P-F group, although it was easily resolved in all cases by 02 administered by mask in a few minutes. Awakening exceeded 10 minutes but no more than 15 minutes in the P-K group, but they were capable of returning home 120 minutes after the procedure. Unpleasant dreams were absent in the P-F group but occurred in 4% in the P-K group. Postoperative psychomotor agitation was 4% in both groups. These 2 drugs produced hemodynamic and respiratory stability during anesthesia with rapid awakening without psycho-hallucinatory phenomena, especially useful in anesthesia of short duration when patients are released in a few hours.

Keywords:

Italy
Clinical Trials
Comparative Studies
Abortion
Anesthesia
Analgesia
Blood Pressure
Side Effects
Europe, Southern
Europe
Developed Countries
Clinical Research
Research Methodology
Studies
Fertility Control, Postconception
Family Planning
Treatment
Hemic System
Physiology
Biology