Title: Modulation of FSH by low-molecular-weight synthetic fragments of human seminal inhibin.

POPLINE Document Number: 075755

Author(s):

Sheth AR
Hurkadli KS
Mahale SD
Iyer KS

Source citation:

In: Growth factors in fertility regulation. Proceedings of the Symposium on Potential of Molecular Biology in Fertility Regulation: Growth Regulatory Factors, jointly sponsored by the World Health Organization and the National Institute of Child Health and Human Development and held at the National Institutes of Health, Bethesda, Maryland, on September 22-24, 1988, edited by Florence P. Haseltine, Jock K. Findlay. Cambridge, England, Cambridge University Press, 1991. :229-34. (Scientific Basis of Fertility Regulation)

Abstract:

A novel decapeptide in the family of inhibin fragments is described that inhibits follicle stimulating hormone (FSH) release in rat, human, monkey, and sheep pituitaries. The inhibin family of proteins isolated from testis, and the related 94-amino acid protein called prostatic inhibin peptide (PIP), all suppress FSH release from the pituitary. The authors synthesized 2 PIP fragments, one a carboxy-terminal nonapeptide which raised FSH in male rats without affecting luteinizing hormone or prolactin levels. This peptide also acts in isolated rat, cattle, monkey, and human pituitaries in vitro. It may be useful to raise FSH for inducing ovulation or treating polycystic ovary. Another synthetic nonapeptide was constructed by adding a tyrosine at the NH2 terminal, thereby blocking the cysteine at position 87. This decapeptide suppressed FSH levels in rats in vivo and in vitro. It has the advantage of being more easily produced and is probably less antigenic than other peptides in the inhibin family.

Keywords:

Research Report
Clinical Research
In Vitro
Animals, Laboratory
Follicle Stimulating Hormone
Endocrine Effects
Hormones
Proteins
Prostate
Research Methodology
Gonadotropins, Pituitary
Gonadotropins
Endocrine System
Physiology
Biology
Genitalia, Male
Genitalia
Urogenital System