POPLINE Document Number: 081232
Author(s):
Jones MW
Silverberg SG
Kurman RJ
Source citation:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 1993;12(1):1-7.
Abstract:
The authors reviewed the clinical and pathological features of 24 cases of well-differentiated villoglandular adenocarcinoma of the uterine cervix. The patients' ages ranged from 27 to 54 years, with an average age of 37. At least 15 patients were taking oral contraceptives prior to diagnosis, compared to 5 of 18 in a control group of patients with various other histologic types of cervical adenocarcinoma. All of the neoplasms were exophytic polypoid lesions with thick or thin papillae lines by endocervical, endometrial, or intestinal-type epithelium showing mild cytologic atypia. 10 were associated with adenocarcinoma in situ, 8 with cervical intraepithelial neoplasia, and 1 with microglandular hyperplasia. All tumors were confined to the cervix. 5 patients were treated by excisional biopsy or cone biopsy, 4 by simple hysterectomy with prior or subsequent radiation therapy, and 15 by radical hysterectomy. All patients are alive and well, with no evidence of recurrent disease. The followup ranged from 7 to 77 months, with a mean of 36 months. (author's)
Keywords:
United StatesIndex page
Retrospective Studies
Cervical Cancer
Control Groups
Oral Contraceptives, Side Effects
Histology
Laboratory Examinations and Diagnoses
Treatment
Contraceptive Methods
Side Effects
Developed Countries
North America
Americas
Studies
Research Methodology
Cancer
Neoplasms
Diseases
Contraceptive Safety
Safety
Public Health
Health
Biology
Examinations and Diagnoses
Contraception
Family Planning