POPLINE Document Number: 075654
Author(s):
Bustos HH
Huber R
Baptista H
Izquierdo H
Sanchez Contreras J
Source citation:
Ginecología y Obstetricia de México, 1992 Jan;60:22-6.
Abstract:
In a retrospective case control study of 96 obstetrical patients 48 cases had partial thromboplastin time (TTPA) with kaolin over 4 seconds compared with the test group. The control group of 48 women with normal TTPA were also studied. Age, socioeconomic status, weight, family and personal illness history were included. Habitual abortion,neonatal death, and hypertension were recorded. The average TTPA value was 53.6 +or- 7.87 seconds for the case group vs 38.8 =or- 4.9 for the controls which was not statistically significant. No statistical significance was found regarding age, start of menarche, nutritional and socioeconomic status, and blood group. The body weight of the case group was higher with 58.5 kg =or- 14.4 kg (a range of 43.4-81.4 kg). There were 7 cases of thrombophlebitis (14.5%) in the lower extremities in the case group and none in the controls. There were 7 cases of habitual abortion in the case group defined as 3 or more miscarriages before 20 weeks of gestation vs 2 cases in controls. There were 4 cases of neonatal deaths associated with premature delivery in the case groups and none in controls. Acute hypertensive disease associated with pregnancy totaled to 8 cases in the 1st group (16.6%) and 4 cases in controls (8.3%). In both groups there were 2 cases of fetal death. In the case group there was 1 case of chromosomopathy and in the control group 1 case of premature expulsion of placenta. The TTPAs test is used mostly for the initial phase of studying patients suspected of having lupus anticoagulant (LA). LA belongs to abnormalities characterized by the presence of antiphospholipid antibodies. It is often used for diagnosing initial stages of autoimmunity which can frequently occur in thrombotic process, fetal loss, intrauterine growth retardation, and increased hypertensive illness in pregnancy.
Keywords:
Case Control StudiesIndex page
Retrospective Studies
Mexico
Pregnancy Complications
Thrombophlebitis
Blood Coagulation Effects
Abortion, Spontaneous
Hypertension
Testing
Systemic Lupus Erythematosus
Autoimmune Response
Studies
Research Methodology
North America
Latin America
Americas
Developing Countries
Diseases
Thromboembolism
Embolism
Vascular Diseases
Hematological Effects
Hemic System
Physiology
Biology
Measurement
Antibodies
Immunologic Factors
Immunity
Immune System