Title: The spermicide nonoxynol-9 does not inhibit Chlamydia trachomatis in vitro.

POPLINE Document Number: 050663

Author(s):

Kappus EW
Quinn TC

Source citation:

Sexually Transmitted Diseases, 1986 Jul-Sep;13(3):134-7.

Abstract:

The antimicrobial effects of the active ingredient, nonoxynol-9, and the base component of a commercially available spermicide were tested in vitro against Chlamydia trachomatis. The infectivity cell-free elementary bodies was not affected by nonoxynol-9 or the base after incubation for 30, 60, or 180 minutes in direct contact with serial 2- fold dilutions of each agent. The spermicide's effect on the in vitro growth of C. trachomatis was evaluated after exposure of C. trachomatis- infected McCoy cells to serial dilutions of each agent for 2 hours and for 72 hours. A significant cytopathic effect of nonoxynol-9 on the host cell membrane was observed at concentrations of spermicide between 100% and 0.0014%. However neither agent was effective in inhibiting the intracellular growth of C. trachomatis at concentrations (0.0014- 0.0004%) of nonoxynol-9 that produced no evident cytopathic effect on McCoy cells. Thus, nonoxynol-9 was found to be ineffective in inhibiting infectivity or subsequent growth of C. trachomatis. (author's)

Keywords:

In Vitro
Nonoxynol
Evaluation
Chlamydia
Laboratory Examinations and Diagnoses
Prevention and Control
Clinical Research
Research Methodology
Alcohols
Organic Chemicals
Ingredients and Chemicals
Sexually Transmitted Diseases
Reproductive Tract Infections
Infections
Diseases
Examinations and Diagnoses