Title: Environmental influences on fertility, pregnancy, and development: strategies for measurement and evaluation. Proceedings of a meeting held in Cincinnati, Ohio, May 24 and 25, 1982.

POPLINE Document Number: 042413

Author(s):

Legator MS
Rosenberg MJ
Zenick H

Source citation:

New York, New York, Alan R. Liss, 1984. ix, 177 p.

Abstract:

The papers included in this document, originally presented in a workshop held May 24-25, 1982, address environmental influences on fertility, pregnancy, and reproductive outcomes. Participants attempted to deal with research priorities, the utility of various research strategies, methodological and design considerations in the selection of end points to be evaluated, and the contribution of animal data to human studies. This selection of papers makes it apparent that discussion covers a spectrum of chemically induced adverse health outcomes including prezygotic effects, effects during in utero exposure, as well as genetic damage induced during spermatogenesis and detected in the F1 generation. Zenick et al. deals with teratogenic studies in rodents. Lewis reviews various approaches for evaluating genetic damage in the mouse including identifying genetic mutations by scoring mice for various enzyme activities. Adams et al. describe the induction of behavioral anomalies in rats following chemical exposure during spermatogenesis. The sperm morphology studies of Wyrobek presents a technique for monitoring adverse effects in both animals and man. The studies of Omenn, Rosenberg and Halperin, Whorton, Hogue, and Scialli and Fabro summarize the status of human monitoring studies for reproductive outcomes and present examples of what has been learned from past experiences with chemicals such as dibromochloropropane. The work reported by Peters and Preston-Martin indicates childhood tumors after paternal exposure.

Keywords:

Global
Environment
Environmental Pollution
Fertility
Pregnancy
Reproduction
Research Methodology
Epidemiologic Methods
Conferences and Congresses
Animals, Laboratory
Clinical Research
Research and Development
Ecology
Pregnancy Complications
Diseases
Demographic Factors
Population Dynamics
Population
Pregnancy Outcomes
Genetics
Biology
Spermatogenesis
Behavior
Neoplasms
Environmental Degradation
Technology
Economic Factors