POPLINE Document Number: 650122
Author(s):
Girod C
Chauvineau A
Source citation:
Comptes Rendus de la Societe de Biologie, 1964 Nov 15;158(11):2113-2115.
Abstract:
The testes and accessory glands of 4 pubescent and 6 adult monkeys were examined in histologic sections stained with periodic acid Schiff reagent at various times from 17 hours to 7 months after a single sc injection of 1 ml cadmium chloride (9.12 g/l). In pubescent testis removed 17 hours or 8 days after injection, the diameter of the seminiferous tubules had decreased, and the spermatogonia had ceased spermatogenesis, the germinative cells on the periphery were necrotic, but the Sertoli cells were intact. 3 months later some tubules showed necrotic spermatogonia. In adults, 3 weeks after injection, the seminal vesicles, epididymal epithelium and prostate were atrophied. 3 months later the accessory structures had recovered, by 6-7 months approaching controls. During this time, the Sertoli cells were thriving, spermatogenesis was apparent, but newly formed sex cells were degenerating. Some Leydig cells had a large nuclei with prominent nucleoli.
Keywords:
Animals, LaboratoryIndex page
Testis
Histology
Seminal Vesicles
Spermatogenesis Blocking Agents
Administration and Dosage
Side Effects
Contraceptive Agents, Side Effects
Men
Clinical Research
Research Methodology
Genitalia, Male
Genitalia
Urogenital System
Physiology
Biology
Contraceptive Agents, Male
Contraceptive Agents
Contraception
Family Planning
Drugs
Treatment
Demographic Factors
Population