Title: The effect of progestin and progesterone on ovulation in the rabbit.

POPLINE Document Number: 370004

Author(s):

Makepeace AW
Weinstein GL
Friedman MH

Source citation:

American Journal of Physiology, 1937 Jul;119(3):512-516.

Abstract:

The ability of exogenous progestin derived from the corpora lutea of sows or progesterone to inhibit ovulation was studied in the rabbit. The animals received either 3 rabbit units of progestin or 1-5 mg of progesterone after which attempts at mating were made, most of which were unsuccessful. In those animals in which mating was achieved there was no indication of ovulation in any of the animals 18 hours after mating. The administration of a minimal ovulating dose of pregnancy urine extract immediately after the refusal of mating resulted in ovulation in 7 of 9 animals. It was concluded that progestin inhibits ovulation by interfering with the postcoital release of pituitary gonado tropin hormone.

Keywords:

Animals, Laboratory
Ovulation Suppression
Contraceptive Agents, Progestin
Evaluation
Progesterone
Oral Contraceptives
Clinical Research
Research Methodology
Contraceptive Mode of Action
Contraception
Family Planning
Contraceptive Agents, Female
Contraceptive Agents
Progestational Hormones
Hormones
Endocrine System
Physiology
Biology
Contraceptive Methods