Title: Crystalline progestin.

POPLINE Document Number: 340002

Author(s):

Allen WM
Wintersteiner O

Source citation:

Science, August 24, 1934;80(206):191-192.

Abstract:

The physical and chemical properties of a crystalline material, derived from corpus luteum extract and possessing progestin activity, were analyzed. Compound A, the main constituent of the mixture, is composed of C21 H34 02, melts at 128 degrees, and is physiologically inactive. Compound B is composed of C21 H30 02, melts at 128 degrees, and has the characteristic physiological properties of progestin. Doses of .5-1 mg Compound B cause progestational proliferation in the castrated rabbit. Its potency is tentatively designated as 1 rabbit unit/mg. Compound C is also physiologically active, melts at 120-121 degrees, and is considered an isomorphic modification of Compound B. It is suggested that the name progestin be retained for Compound B because of its physiological action.

Keywords:

Contraceptive Agents, Progestin
Analysis
Contraceptive Agents, Female
Contraceptive Agents
Contraception
Family Planning
Research Methodology